Charton Isabelle, Suzenet Franck, Boutin Jean A, Audinot Valérie, Delagrange Philippe, Bennejean Caroline, Renard Pierre, Guillaumet Gérald
Institut de Chimie Organique et Analytique, UMR-CNRS 6005, Université d'Orléans, rue de Chartres, BP 6759, 45067 Orléans Cedex 02, France.
J Enzyme Inhib Med Chem. 2003 Apr;18(2):187-93. doi: 10.1080/1475636032000096855.
The synthesis of benzoxathiins bearing a retroamide function is described from 8-hydroxythiochroman, the key step involving the synthesis of the benzoxathiin ring through a sulfonium salt. These new melatonin analogues were evaluated on human receptors MT1 and MT2 and have a similar affinity to that of melatonin itself.
