McPherson Heather, Walsh Anne, Silverstone Trevor
Department of Psychological Medicine, Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin, New Zealand.
J Affect Disord. 2003 Sep;76(1-3):121-5. doi: 10.1016/s0165-0327(02)00077-0.
It has been suggested that patients with bipolar disorder may have an increased sensitivity to dopaminergic (DA) compounds. This was investigated by measuring growth hormone (GH) or prolactin (PRL) response to apomorphine (APO), a dopamine receptor agonist, in patients with bipolar depression, unipolar depression and control subjects.
Fourteen patients in an episode of bipolar depression (BP), 15 in an episode of unipolar depression (UP) and 19 age- and gender-matched control subjects (C) participated. The growth hormone (GH) and prolactin (PRL) responses to subcutaneous administration of 0.005 or 0.008 mg/kg APO were measured over 2 h.
The rise in GH was greater with the higher APO dose. Both the GH rise and the PRL fall following APO were similar in BP, UP and C. Neither the GH or PRL responses in BP and UP were affected by successful treatment of the depressive episode.
Our findings do not indicate an altered sensitivity of DA neurones in the hypothalamic-pituitary system in either bipolar or unipolar depression.
有研究表明，双相情感障碍患者可能对多巴胺能（DA）化合物更为敏感。通过测量双相抑郁患者、单相抑郁患者及对照受试者对多巴胺受体激动剂阿扑吗啡（APO）的生长激素（GH）或催乳素（PRL）反应来对此进行研究。
14例处于双相抑郁发作期的患者（BP）、15例处于单相抑郁发作期的患者（UP）以及19例年龄和性别匹配的对照受试者（C）参与了研究。在2小时内测量皮下注射0.005或0.008mg/kg APO后的生长激素（GH）和催乳素（PRL）反应。
较高剂量的APO使GH升高幅度更大。BP组、UP组和C组中，APO注射后GH升高及PRL降低情况相似。双相抑郁发作期和单相抑郁发作期患者的GH或PRL反应均未因抑郁发作的成功治疗而受到影响。
我们的研究结果并未表明双相抑郁或单相抑郁患者下丘脑 - 垂体系统中DA神经元的敏感性发生改变。
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