某些肽对人体多巴胺能功能的影响。
Effect of some peptides on dopaminergic function in man.
作者信息
Lal S, Nair N P, Isaac I, Thavundayil J, Guyda H
机构信息
Douglas Hospital Research Centre, Verdun, Canada.
出版信息
J Neural Transm Suppl. 1990;29:173-81. doi: 10.1007/978-3-7091-9050-0_17.
Thyrotropin-releasing hormone (TRH) (200 micrograms iv) and 1-desamino-8-D-arginine vasopressin (DDAVP) (4 micrograms iv) antagonized the growth hormone (GH) response to apomorphine HCl (Apo) (0.5 mg sc) in 10 normal men. Apo had no effect on basal prolactin (PRL) levels but antagonized the PRL response to TRH. DDAVP plus Apo decreased PRL compared to placebo or DDAVP alone. These observations are compatible with (a) an inhibitory effect of TRH on hypothalamic and pituitary lactotrophe dopamine (DA) function (b) a facilitory effect of DDAVP on lactotrophe DA function and an inhibitory effect on hypothalamic DA function. Whether these are direct or indirect effects on DA mechanisms is unclear.
促甲状腺激素释放激素（TRH）（静脉注射200微克）和1-去氨基-8-D-精氨酸血管加压素（DDAVP）（静脉注射4微克）可拮抗10名正常男性生长激素（GH）对盐酸阿扑吗啡（Apo）（皮下注射0.5毫克）的反应。Apo对基础催乳素（PRL）水平无影响，但可拮抗PRL对TRH的反应。与单独使用安慰剂或DDAVP相比，DDAVP加Apo可降低PRL水平。这些观察结果与以下情况相符：（a）TRH对下丘脑和垂体催乳素细胞多巴胺（DA）功能具有抑制作用；（b）DDAVP对催乳素细胞DA功能具有促进作用，对下丘脑DA功能具有抑制作用。这些对DA机制的影响是直接还是间接尚不清楚。
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