氨氯地平和阿托伐他汀联合治疗对改善高血压合并高脂血症患者的动脉顺应性具有相加作用。
Treatment with amlodipine and atorvastatin have additive effect in improvement of arterial compliance in hypertensive hyperlipidemic patients.
作者信息
Leibovitz Eyal, Beniashvili Maya, Zimlichman Reuven, Freiman Angela, Shargorodsky Marina, Gavish Dov
机构信息
Department of Medicine and the Bruner Institute of Cardiovascular Research, Wolfson Medical Center, Tel Giborim, PO Box 5, Holon, Israel 58100.
出版信息
Am J Hypertens. 2003 Sep;16(9 Pt 1):715-8. doi: 10.1016/s0895-7061(03)00949-x.
BACKGROUND
This study investigates the effect of amlodipine on arterial compliance (AC), and the effect of atorvastatin on AC when given in combination with amlodipine.
METHODS
Twenty-one consecutive hypertensive hyperlipidemic patients were included in this study. Patients were followed every month for 6 months (3 months of amlodipine therapy and 3 months of amlodipine and atorvastatin combination).
RESULTS
During the 3 months of amlodipine monotherapy, large and small AC were improved by 26% and 38%, respectively, and the systemic vascular resistance was reduced by 10%. The addition of atorvastatin during the next 3 months improved small AC by an additional 42% and decreased the systemic vascular resistance by another 5%, but large AC and blood pressure did not change.
CONCLUSIONS
Amlodipine improves large and small AC, and the beneficial effect of atorvastatin on small AC is additive to the effect achieved by amlodipine.
背景
本研究调查氨氯地平对动脉顺应性（AC）的影响，以及阿托伐他汀与氨氯地平联合使用时对AC的影响。
方法
本研究纳入了21例连续的高血压合并高脂血症患者。患者每月随访一次，共6个月（氨氯地平治疗3个月，氨氯地平与阿托伐他汀联合治疗3个月）。
结果
在氨氯地平单药治疗的3个月期间，大AC和小AC分别提高了26%和38%，全身血管阻力降低了10%。在接下来的3个月中添加阿托伐他汀，小AC又额外提高了42%，全身血管阻力又降低了5%，但大AC和血压没有变化。
结论
氨氯地平可改善大AC和小AC，阿托伐他汀对小AC的有益作用是在氨氯地平所取得的效果基础上的叠加。
Zotero 插件