Vesely Stepan, Knutson Tomas, Damber Jan-Erik, Dicuio Mauro, Dahlstrand Christer
Department of Urology, Sahlgrenska University Hospital, Göteborg, Swerden.
Scand J Urol Nephrol. 2003;37(4):322-8. doi: 10.1080/00365590310014760.
To estimate the relationship between age and the values of different diagnostic tests in men with lower urinary tract symptoms (LUTS) suggestive of benign prostatic enlargement (BPE) and to compare prostate growth curves between the normal population sample, healthy men and men with LUTS.
A series of 354 men (mean age 70.2 years; range 45-91 years) with LUTS due to BPE were stratified into seven age groups and reviewed retrospectively. All patients underwent a standard evaluation, involving determination of the International Prostate Symptom Score (IPSS), digital rectal examination, uroflowmetry, determination of the prostate-specific antigen (PSA) level and transrectal ultrasonography. Descriptive statistics were used to describe all the variables and Spearman's correlation test was used to evaluate the relationships between them.
The mean prostate volume was 40.1 (+/-23.9) cm(3) and mean PSA concentration 3.9 (+/-4.2) ng/ml. Both values increased progressively from 27.5 ml and 1.5 ng/ml, respectively in the <54 years age group to 48.2 ml and 5.4 ng/ml, respectively in the <80 years age group. However, in the 75-79 years age group there was a decrease in both prostate volume and symptom score; PSA concentration remained unchanged and maximal flow rate increased slightly. A statistically significant but weak correlation was found between prostate volume and age (r = 0.25, p < 0.0001) and between PSA and age (r = 0.28, p < 0.0001). Prostate volume correlated positively with serum PSA (r = 0.54, p < 0.0001). The correlations between maximum flow rate and age, prostate volume, PSA and IPSS were r = -0.21, p < 0.0001; r = -0.18, p < 0.0006; r = -0.29, p < 0.0001; and r = 0.14, p < 0.0098, respectively.
These data confirm that prostate volume and serum PSA concentration are significantly correlated and increase with advanced age. The correlations between uroflowmetry (Qmax) and age, prostate volume, serum PSA and IPSS were also significant. However, there was no relationship between symptoms and objective measures of BPE. The increase in different parameters of the severity of benign prostatic hyperplasia with advanced age is not continuous. The prostate volume alone is not useful in the estimation of disease severity.
评估年龄与提示良性前列腺增生（BPE）的下尿路症状（LUTS）男性患者不同诊断检查结果之间的关系，并比较正常人群样本、健康男性和LUTS男性的前列腺生长曲线。
回顾性分析354例因BPE导致LUTS的男性患者（平均年龄70.2岁；范围45 - 91岁），将其分为7个年龄组。所有患者均接受了标准评估，包括国际前列腺症状评分（IPSS）测定、直肠指检、尿流率测定、前列腺特异性抗原（PSA）水平测定及经直肠超声检查。采用描述性统计描述所有变量，并使用Spearman相关性检验评估它们之间的关系。
平均前列腺体积为40.1（±23.9）cm³，平均PSA浓度为3.9（±4.2）ng/ml。这两个值均从<54岁年龄组的27.5 ml和1.5 ng/ml分别逐渐增加至<80岁年龄组的48.2 ml和5.4 ng/ml。然而，在75 - 79岁年龄组，前列腺体积和症状评分均下降；PSA浓度保持不变，最大尿流率略有增加。前列腺体积与年龄之间存在统计学显著但较弱的相关性（r = 0.25，p < 0.0001），PSA与年龄之间也存在相关性（r = 0.28，p < 0.0001）。前列腺体积与血清PSA呈正相关（r = 0.54，p < 0.0001）。最大尿流率与年龄、前列腺体积、PSA和IPSS之间的相关性分别为r = -0.21，p < 0.0001；r = -0.18，p < 0.0006；r = -0.29，p < 0.0001；r = 0.14，p < 0.0098。
这些数据证实前列腺体积与血清PSA浓度显著相关且随年龄增长而增加。尿流率（Qmax）与年龄、前列腺体积、血清PSA和IPSS之间的相关性也很显著。然而，症状与BPE的客观指标之间没有关系。良性前列腺增生严重程度的不同参数随年龄增长的增加并非连续的。仅前列腺体积对疾病严重程度的评估并无帮助。
