Schröcksnadel H, Herold M, Steckel-Berger G, Fuchs D, Wachter H, Dapunt O
Universitätsklinik für Frauenheilkunde, Innsbruck.
Geburtshilfe Frauenheilkd. 1992 Oct;52(10):592-5. doi: 10.1055/s-2007-1023190.
Cytokines (IL-1, sIL-2R, IL-3, IL-6, TNF-alpha, IFN-gamma, GM-CSF and neopterin) were measured in sera of 37 patients with hypertensive disorders of pregnancy, 10 healthy pregnant and 10 healthy non-pregnant controls. With the exception of neopterin (p = 0.004) there were no statistically significant differences in cytokine concentrations between healthy pregnant and non-pregnant controls. No statistically relevant differences between healthy pregnant women and hypertensive patients could be found in cytokines of T-lymphocytic origin except GM-CSF in patients with HELLP syndrome (p = 0.02). Elevated levels of IL-6, TNF-alpha and neopterin were observed in hypertensive women. Differences to healthy pregnant controls were statistically significant for IL-6 (p = 0.008), TNF-alpha (p = 0.009) and neopterin (p = 0.04) and were more pronounced in severe forms of the disease. These 3 parameters of monocytic origin showed significant positive correlations amongst each other. A participation of cell-mediated immunity (especially monocytes/macrophages) in the pathomechanism of hypertensive disorders of pregnancy can thus be assumed.
在37例妊娠高血压疾病患者、10例健康孕妇和10例健康非孕对照者的血清中检测了细胞因子（白细胞介素-1、可溶性白细胞介素-2受体、白细胞介素-3、白细胞介素-6、肿瘤坏死因子-α、干扰素-γ、粒细胞-巨噬细胞集落刺激因子和新蝶呤）。除新蝶呤外（p = 0.004），健康孕妇和非孕对照者之间细胞因子浓度无统计学显著差异。在T淋巴细胞来源的细胞因子方面，除了HELLP综合征患者的粒细胞-巨噬细胞集落刺激因子（p = 0.02）外，健康孕妇和高血压患者之间未发现统计学相关差异。高血压女性中观察到白细胞介素-6、肿瘤坏死因子-α和新蝶呤水平升高。与健康孕妇对照相比，白细胞介素-6（p = 0.008）、肿瘤坏死因子-α（p = 0.009）和新蝶呤（p = 0.04）的差异具有统计学意义，且在疾病的严重形式中更为明显。这3个单核细胞来源的参数之间显示出显著的正相关。因此，可以假设细胞介导的免疫（尤其是单核细胞/巨噬细胞）参与了妊娠高血压疾病的发病机制。
