Abraham George, Paing Wynn Wynn, Kaminski Joanne, Joseph Ashok, Kohegyi Eva, Josiassen Richard C
Arthur P. Noyes Research Foundation, 1001 Sterigere Street, Norristown, PA 19401, USA.
Am J Psychiatry. 2003 Sep;160(9):1618-20. doi: 10.1176/appi.ajp.160.9.1618.
This study was designed to prospectively examine differential effects of sustained "high" and "low" serum prolactin levels on bone mineral density and peripheral markers of bone metabolism.
A dual-energy X-ray absorptiometer was used to measure bone mineral density. Peripheral markers of bone formation and resorption were used to measure bone metabolism in 14 Caucasian female patients with schizophrenia treated with risperidone or olanzapine monotherapy over 12 months.
Analyses of variance failed to show an association between elevated prolactin and bone mineral loss over time. However, higher rates of bone formation and resorption were seen in those with high prolactin levels.
The results failed to show that elevated prolactin accelerates bone mineral density loss. However, sustained hyperprolactinemia did have an impact on the rate of bone metabolism. Perhaps higher prolactin levels over longer time periods are necessary before the metabolic processes become uncoupled, leading to bone mineral density loss.
本研究旨在前瞻性地探讨持续的“高”和“低”血清催乳素水平对骨密度及骨代谢外周标志物的不同影响。
使用双能X线吸收仪测量骨密度。采用骨形成和骨吸收的外周标志物，对14例接受利培酮或奥氮平单药治疗12个月的白人女性精神分裂症患者的骨代谢情况进行测量。
方差分析未显示催乳素升高与随时间推移的骨矿物质流失之间存在关联。然而，催乳素水平高的患者骨形成和骨吸收的速率更高。
结果未能表明催乳素升高会加速骨密度流失。然而，持续性高催乳素血症确实对骨代谢速率有影响。或许在代谢过程出现解偶联导致骨密度流失之前，需要更长时间的较高催乳素水平。
