Sekine Yoshimoto, Minabe Yoshio, Ouchi Yasuomi, Takei Nori, Iyo Masaomi, Nakamura Kazuhiko, Suzuki Katsuaki, Tsukada Hideo, Okada Hiroyuki, Yoshikawa Etsuji, Futatsubashi Masami, Mori Norio
Department of Psychiatry and neurology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, 431-3192 Shizuoka, Japan.
Am J Psychiatry. 2003 Sep;160(9):1699-701. doi: 10.1176/appi.ajp.160.9.1699.
The authors examined dopamine transporter density in the orbitofrontal cortex, dorsolateral prefrontal cortex, and amygdala in methamphetamine users and assessed the relationship of these measures to the subjects' clinical characteristics.
Positron emission tomography with [(11)C]WIN 35,428 was used to examine the regions of interest in 11 methamphetamine users and nine healthy comparison subjects. Psychiatric symptoms were evaluated with the Brief Psychiatric Rating Scale.
Dopamine transporter density in the three regions studied was significantly lower in the methamphetamine users than in the comparison subjects. The lower dopamine transporter density in the orbitofrontal and dorsolateral prefrontal cortex was significantly correlated with the duration of methamphetamine use and the severity of psychiatric symptoms.
Chronic methamphetamine use may cause dopamine transporter reduction in the orbitofrontal cortex, dorsolateral prefrontal cortex, and amygdala in the brain. Psychiatric symptoms in methamphetamine users may be attributable to the decrease in dopamine transporter density in the orbitofrontal cortex and the dorsolateral prefrontal cortex.
作者检测了甲基苯丙胺使用者眶额皮质、背外侧前额叶皮质和杏仁核中的多巴胺转运体密度，并评估了这些测量值与受试者临床特征之间的关系。
使用[（11）C]WIN 35,428进行正电子发射断层扫描，以检测11名甲基苯丙胺使用者和9名健康对照受试者的感兴趣区域。使用简明精神病评定量表评估精神症状。
所研究的三个区域中的多巴胺转运体密度在甲基苯丙胺使用者中显著低于对照受试者。眶额皮质和背外侧前额叶皮质中较低的多巴胺转运体密度与甲基苯丙胺使用时间和精神症状严重程度显著相关。
长期使用甲基苯丙胺可能导致大脑中眶额皮质、背外侧前额叶皮质和杏仁核中的多巴胺转运体减少。甲基苯丙胺使用者的精神症状可能归因于眶额皮质和背外侧前额叶皮质中多巴胺转运体密度的降低。
