Wyss P, Rageth J C, Unger C, Hochuli E
Universitätsfrauenklinik Zürich.
Geburtshilfe Frauenheilkd. 1992 Oct;52(10):611-6. doi: 10.1055/s-2007-1023194.
It is generally accepted that breast cancer with positive steroid receptors has a better prognosis than with negative receptors. The aim of this study was to analyse the influence of the oestrogen (ER) and progesterone (PR) receptors regarding disease-free interval (DFI) and overall (oa) survival of 441 patients operated on in the Department of Gynaecology of the University Hospital of Zürich. Analysis of the subgroups separated according to menopausal status showed the following results: Premenopausal patients (n = 135): Only PR have a significant influence on the oa-survival (p = 0.0370), not the ER. The DFI was independent of ER and PR positive findings. Postmenopausal patients (n = 306): In this group only the ER has a significant influence (p = 0.0296) on the oa-survival, not the PR. Both steroid receptors did not have any influence regarding DFI. Metastases and local recurrence occur pre- and postmenopausaly approximately at the same time, independent of the quality of the steroid receptors. The better oa-survival despite the same DFI can be explained by a better response to the therapy by patients in the premenopause with positive PR status and patients in the postmenopause with positive ER status.
一般认为，类固醇受体阳性的乳腺癌患者预后优于受体阴性的患者。本研究的目的是分析雌激素（ER）和孕激素（PR）受体对苏黎世大学医院妇科接受手术的441例患者的无病生存期（DFI）和总生存期（oa）的影响。根据绝经状态进行分组分析，结果如下：绝经前患者（n = 135）：只有PR对oa生存期有显著影响（p = 0.0370），而ER无此影响。DFI与ER和PR阳性结果无关。绝经后患者（n = 306）：在该组中，只有ER对oa生存期有显著影响（p = 0.0296），而PR无此影响。两种类固醇受体对DFI均无影响。绝经前后转移和局部复发的发生时间大致相同，与类固醇受体的情况无关。尽管DFI相同，但oa生存期更好的原因可以解释为绝经前PR状态阳性的患者和绝经后ER状态阳性的患者对治疗的反应更好。
