Padmavathy B, Devaraj S N, Devaraj H
Department of Biochemistry, University of Madras.
Indian J Biochem Biophys. 1992 Dec;29(6):522-4.
Administration of amiodarone (AD) to rats leads to marked damage to liver, as evidenced by pathological changes and significant increases in activities of serum marker enzymes and levels of lipids like cholesterol and phospholipids with no alteration in the triglyceride levels. The risk factor, that is the total cholesterol/HDL cholesterol ratio, exhibited increase in the experimental animals, indicating that amiodarone treatment may lead to the development of coronary heart disease.
给大鼠施用胺碘酮（AD）会导致肝脏明显受损，病理变化以及血清标志物酶活性和胆固醇、磷脂等脂质水平显著升高可证明这一点，而甘油三酯水平没有改变。风险因素，即总胆固醇/高密度脂蛋白胆固醇比值，在实验动物中有所增加，表明胺碘酮治疗可能会导致冠心病的发生。
