Maulik G, Ghosh N, Sengupta T, Chattopadhyay D, Chakraborty A K, Chatterjee G C
Department of Biochemistry, University College of Science, Calcutta, India.
Indian J Exp Biol. 1992 Dec;30(12):1166-9.
Acute single dose administration of lanthanum chloride (250 mg/kg body wt, ip) to chicks have been found to alter the levels of enzymes of the antioxidant defence system of chick renal cortex fractions. Such changes involved significant decrease in activities of glucose-6-phosphate dehydrogenase, glutathione reductase, glutathione peroxidase and catalase of kidney epithelial cells. However glutathione-S-transferase activity was not altered. Glutathione and total thiol contents were decreased while lipoperoxidative reactions in kidney-cortex was significantly enhanced. The data indicate that amelioration of lanthanum toxicity condition by methionine supplementation may be due to the methionine serving as a precursor of glutathione.
已发现，对雏鸡急性单次腹腔注射氯化镧（250毫克/千克体重）会改变雏鸡肾皮质部分抗氧化防御系统的酶水平。这些变化包括肾上皮细胞中葡萄糖-6-磷酸脱氢酶、谷胱甘肽还原酶、谷胱甘肽过氧化物酶和过氧化氢酶的活性显著降低。然而，谷胱甘肽-S-转移酶的活性没有改变。谷胱甘肽和总硫醇含量降低，而肾皮质中的脂质过氧化反应显著增强。数据表明，补充蛋氨酸改善镧毒性状况可能是由于蛋氨酸作为谷胱甘肽的前体。
