Kiseleva I V, Grigor'eva E P, Naĭkhin A N, Ivanova V V, Larionova N V, Donina S A, Litvinova O M, Aleksandrova G I, Rudenko L G
Vopr Virusol. 2003 Jul-Aug;48(4):26-9.
The influence of ts-phenotype of epidemic viruses and of cold-adapted (CA) reassortant vaccines' strains, appropriately prepared, produced on the human immunogenicity was under investigation. A widespread variability of epidemic viruses' thermal sensitivity sign was established. It was shown that the CA reassortant vaccine strains, obtained through crossbreeding of attenuation donors and of thermally resistant epidemic viruses, are described by a higher immunogenicity. Therefore, the immunogenicity of live influenza vaccines (LIV) can be defined by the ts-phenotype of epidemic parent viruses, which must be sampled for the reassortant vaccine strains not only through searching for samples of antigenically actual viruses but also through search for non-ts-phenotype viruses.
正在研究流行病毒的ts表型以及适当制备的冷适应（CA）重配疫苗株对人体免疫原性的影响。已确定流行病毒热敏感性标志存在广泛变异性。结果表明，通过减毒供体与耐热流行病毒杂交获得的CA重配疫苗株具有更高的免疫原性。因此，活流感疫苗（LIV）的免疫原性可由流行亲代病毒的ts表型来定义，为获得重配疫苗株而采集的亲代病毒样本不仅要通过寻找抗原性实际病毒的样本，还要通过寻找非ts表型病毒。
