Podeschwa Michael A L, Plettenburg Oliver, Altenbach Hans-Josef
Institut für Organische Chemie, Bergische Universität Wuppertal, Gaussstrasse 20, 42097 Wuppertal, Germany.
Org Biomol Chem. 2003 Jun 7;1(11):1919-29. doi: 10.1039/b302622a.
A practical route is described for the preparation of azido-myo-inositols, amino-myo-inositols and azido-conduritol B derivatives. Starting from p-benzoquinone, optically pure compounds in both forms can be prepared via enzymatic resolution of a derived diacetoxy conduritol B derivative. Selective introduction of nitrogen-containing functional groups in four of the six possible positions in the cyclitol moiety is followed by further functionalization to yield the target compounds.
描述了一种制备叠氮基肌醇、氨基肌醇和叠氮基卫矛醇B衍生物的实用路线。从对苯醌开始，通过衍生的二乙酰氧基卫矛醇B衍生物的酶促拆分，可以制备两种形式的光学纯化合物。在环醇部分六个可能位置中的四个位置选择性引入含氮官能团，然后进一步官能化以得到目标化合物。
