Croft R J, Gonsalvez C J, Gabriel C, Barry R J
Neuropsychopharmacology, Swinburne University of Technology, Melbourne, Australia.
Psychophysiology. 2003 May;40(3):322-8. doi: 10.1111/1469-8986.00036.
The P3(00) is an electrophysiological index of neural processing that varies with such stimulus parameters as interstimulus interval (ISI) and target probability, with a common view being that it reflects an endogenous form of memory update. Building on previous research, we argue that relations between P3 amplitude and both ISI and probability may be attributable to the target-to-target interval (TTI). Employing between-subject (Experiment 1; N = 24) and within-subject (Experiment 2; N = 10) designs, the present paper addresses this by testing subjects on a standard two-tone auditory oddball task as well as a one-tone task. In both studies, P3 amplitude increased and latency decreased linearly with TTI, and these relations were relatively unaffected by ISI or probability. This suggests that ISI and probability per se do not independently affect P3 amplitude, and that TTI offers a strong explanation of the reported relations between P3 amplitude and both ISI and probability.
P3(00)是一种神经加工的电生理指标，它会随刺激间隔（ISI）和目标概率等刺激参数而变化，普遍观点认为它反映了一种内源性的记忆更新形式。基于先前的研究，我们认为P3波幅与ISI和概率之间的关系可能归因于目标到目标的间隔（TTI）。本文采用组间设计（实验1；N = 24）和组内设计（实验2；N = 10），通过让受试者完成标准的双音听觉oddball任务以及单音任务来探讨这一问题。在两项研究中，P3波幅均随TTI呈线性增加，潜伏期随TTI呈线性缩短，并且这些关系相对不受ISI或概率的影响。这表明ISI和概率本身并不会独立影响P3波幅，并且TTI为所报道的P3波幅与ISI和概率之间的关系提供了有力的解释。
