Berger-Sweeney Joanne
Department of Biological Sciences, Wellesley College, 106 Central Street, Wellesley, MA 02481, USA.
Neurosci Biobehav Rev. 2003 Sep;27(4):401-11. doi: 10.1016/s0149-7634(03)00070-8.
This review seeks to address, though perhaps not answer fully, four important questions about the cholinergic basal forebrain (BF) system in developing mammals. First, what role does the cholinergic basal forebrain system play in the development of cognitive functions? Second, does the cholinergic BF system play a fundamentally similar role in development vs. adulthood? Third, does sexual dimorphism of the developing cholinergic BF system influence cognition differently in the two sexes? Finally, what role does the developing cholinergic BF system play in developmental disorders such as Down syndrome and Rett syndrome? Examples from the literature, primarily studies in mice and rats, are given in an attempt to answer these important questions.
本综述旨在探讨（尽管可能无法完全回答）关于发育中的哺乳动物胆碱能基底前脑（BF）系统的四个重要问题。第一，胆碱能基底前脑系统在认知功能发育中起什么作用？第二，胆碱能BF系统在发育过程与成年期所起的作用在本质上是否相似？第三，发育中的胆碱能BF系统的性别差异是否对两性的认知有不同影响？最后，发育中的胆碱能BF系统在诸如唐氏综合征和雷特综合征等发育障碍中起什么作用？文中给出了文献中的实例，主要是对小鼠和大鼠的研究，以试图回答这些重要问题。
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