Parker J, Smarr K, Anderson S, Hewett J, Walker S, Bridges A, Caldwell W
Harry S Truman Memorial Veterans Hospital, University of Missouri-Columbia School of Medicine 65201.
J Rheumatol. 1992 Dec;19(12):1901-5.
We investigated the relationship between changes in helplessness and depression to disease activity in rheumatoid arthritis (RA). Sixty-three men with RA were examined at baseline, 3 months, and 6 months. Joint counts, immunophenotypic analyses of peripheral blood lymphocytes, and measures of psychological status were obtained at each examination. Zero-order correlations between psychological change and disease activity change from baseline to 6 months were not significant, but hierarchical multiple regression analyses revealed that changes in affective state were significantly related to joint counts at 6 months. Additionally, changes in absolute numbers of HLA-DR+ (human leukocyte antigen DR type) cells were significantly related to joint counts at 6 months. When absolute numbers of HLA-DR+ cells were entered prior to affective state in a hierarchical multiple regression, affective state was only marginally statistically significant. The study shows that longitudinal relationships between affective changes and disease activity are moderated by intervening variables such as immunologic activation.
我们研究了类风湿关节炎（RA）患者中无助感和抑郁情绪的变化与疾病活动之间的关系。对63名男性RA患者在基线期、3个月和6个月时进行了检查。每次检查时均获取关节计数、外周血淋巴细胞的免疫表型分析结果以及心理状态测量值。从基线期到6个月，心理变化与疾病活动变化之间的零阶相关性不显著，但分层多元回归分析显示，情感状态的变化与6个月时的关节计数显著相关。此外，HLA-DR+（人类白细胞抗原DR型）细胞绝对数量的变化与6个月时的关节计数显著相关。在分层多元回归中，当HLA-DR+细胞绝对数量先于情感状态进入模型时，情感状态仅具有微弱的统计学意义。该研究表明，情感变化与疾病活动之间的纵向关系受到免疫激活等干预变量的调节。
