Ding H, Wang F, Lin F, Su C
Institute of BME, Dept of Electrical Eng., Tsinghua University, 100084 Beijing.
Guang Pu Xue Yu Guang Pu Fen Xi. 2001 Apr;21(2):155-9.
The phenomena of photon migration in multi-layered structures of biological tissue is very important in the field of non-invasive near-infrared optical diagnosis. In this paper, a two-layered structure consisting of the fat and the muscle of poke was used as the sample. Near-infrared light source and detector were located on the surface of the fat and a part of the photons reflected by the two-layered structure of the tissue were detected. The relationship between the optical current and the distance from source to detector and the relationship between the optical current and the thickness of the fat layer were given. In order to analyze the experiment results, Monte-Carlo simulation was used to calculate the photons migration traces in the uniform tissues and the Fresnel's law is used to determine the refraction and reflection components of a photon package at the boundary between the fat and the muscle. The results showed that the simulation data coincident well with the experimental results. The conclusion is that the experiment and the simulation method provided in this study may be useful to analyze the photon migration in a mult-layered tissue and to optimize the design of the transducer.
光子在生物组织多层结构中的迁移现象在无创近红外光学诊断领域非常重要。本文以由猪的脂肪和肌肉组成的双层结构作为样本。近红外光源和探测器位于脂肪表面，检测到了由组织双层结构反射的部分光子。给出了光电流与光源到探测器距离之间的关系以及光电流与脂肪层厚度之间的关系。为了分析实验结果，使用蒙特卡罗模拟来计算光子在均匀组织中的迁移轨迹，并使用菲涅尔定律来确定光子包在脂肪和肌肉边界处的折射和反射分量。结果表明，模拟数据与实验结果吻合良好。结论是，本研究中提供的实验和模拟方法可能有助于分析光子在多层组织中的迁移，并优化换能器的设计。
