Shotelersuk K, Rojpornpradit P, Chottetanaprasit T, Lertbutsayanukul C, Lertsanguansinchai P, Khorprasert C, Asavametha N, Suriyapee S, Jumpangern C
Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Med Assoc Thai. 2003 Jul;86(7):603-11.
A retrospective study was performed on 69 patients with intracranial germ cell tumors who were treated at the Division of Radiation Oncology, Department of Radiology, King Chulalongkorn Memorial Hospital from 1990 to 2000. Median age was 15 years. Forty-two cases (60.87%) had histologically confirmed germinoma or nongerminomatous germ cell tumors. Germinoma was the predominate histology followed by mixed germ cell tumors. Pineal and suprasellar regions were the two leading sites, hydrocephalus (85.5%) and diplopia (57.97%) were the two most common clinical presentations. Only 13 cases had the result of cerebrospinal fluid (CSF) cytology or magnetic resonance imagine (MRI) of the spine before initial treatment. Serum tumor markers, Alpha fetoprotein and beta-human chorionic gonadotropin, were available in 66.67 per cent. Total or partial tumor removal were feasible in 24 cases. Whole brain irradiation was given in almost all cases with the median dose of 3,600 cGy. The median total tumor dose was 5,400 cGy. Whole spine radiation was utilized in 17 cases. The mean follow-up time was 41 months. The five-year disease free survival was 73.59 per cent. Overall 3 and 5 year survival rates were 86.45 per cent and 81.64 per cent, respectively.
对1990年至2000年期间在朱拉隆功国王纪念医院放射科放射肿瘤学部门接受治疗的69例颅内生殖细胞瘤患者进行了一项回顾性研究。中位年龄为15岁。42例（60.87%）经组织学证实为生殖细胞瘤或非生殖细胞性生殖细胞瘤。生殖细胞瘤是主要的组织学类型，其次是混合性生殖细胞肿瘤。松果体区和鞍上区是两个主要部位，脑积水（85.5%）和复视（57.97%）是两种最常见的临床表现。只有13例在初始治疗前有脑脊液（CSF）细胞学检查结果或脊柱磁共振成像（MRI）结果。66.67%的患者可检测血清肿瘤标志物甲胎蛋白和β-人绒毛膜促性腺激素。24例可行肿瘤全部或部分切除。几乎所有病例均给予全脑照射，中位剂量为3600 cGy。肿瘤总中位剂量为5400 cGy。17例采用全脊柱放疗。平均随访时间为41个月。五年无病生存率为73.59%。总的3年和5年生存率分别为86.45%和81.64%。
