Julasareekul Wichian, Eiam-Ong Somchai, Bejraputra Ornanong, Seublinvong Tada
Nephrology Unit, Medicine, Queen Sawangwatana Memorial Hospital, Chon Buri 20110, Thailand.
J Med Assoc Thai. 2003 Aug;86(8):766-71.
Pharmacokinetic studies of mycophenolic acid (MPA) were performed in 16 stable Thai kidney transplant recipients treated with 1 g/d of mycophenolate mofetil (MMF). The complete area under the blood concentration-time curve (AUC) of MPA was determined using the linear trapezoidal rule from 8 concentrations at, 0, 1, 2, 3, 4, 6, 8, and 12 h after MMF administration. The mean values of AUC(0-12) were 37.54 + 0.80 microg x h/ml. MPA concentrations at 8 h after dosing, not the trough or maximum levels, showed the best correlation with AUC(0-12) (r2 = 0.72). The equation model of abbreviated AUC of MPA, derived by multiple linear regression analysis, that had the highest correlation (r2) and lowest absolute prediction error (APE) was: AUC = 0.6 C1 + 1.9 C3 + 8.68 C8 + 4.65 (r2 = 0.92, APE = 2.05 +/- 0.32%). The best abbreviated AUC equations obtained by linear trapezoidal rule were: AUC = 4.5 C0 + C1 + 1.5 C2 + 5 C4 (r2 = 0.78, APE = 5.78 +/- 1.14%) and AUC = 5 C0 + C1 + C2 + 5 C3 (r2 = 0.76, APE = 6.21 +/- 1.46%).
对16名接受1克/天霉酚酸酯（MMF）治疗的稳定泰国肾移植受者进行了霉酚酸（MPA）的药代动力学研究。MPA血药浓度-时间曲线下的完整面积（AUC）采用线性梯形法则，根据MMF给药后0、1、2、3、4、6、8和12小时的8个浓度值来确定。AUC(0 - 12)的平均值为37.54 + 0.80微克·小时/毫升。给药后8小时的MPA浓度，而非谷浓度或最高浓度，与AUC(0 - 12)显示出最佳相关性（r2 = 0.72）。通过多元线性回归分析得出的MPA简化AUC方程模型，其相关性（r2）最高且绝对预测误差（APE）最低，为：AUC = 0.6 C1 + 1.9 C3 + 8.68 C8 + 4.65（r2 = 0.92，APE = 2.05 +/- 0.32%）。通过线性梯形法则获得的最佳简化AUC方程为：AUC = 4.5 C0 + C1 + 1.5 C2 + 5 C4（r2 = 0.78，APE = 5.78 +/- 1.14%）和AUC = 5 C0 + C1 + C2 + 5 C3（r2 = 0.76，APE = 6.21 +/- 1.46%）。
