单纯收缩期高血压与血管疾病风险

Isolated systolic hypertension and the risk of vascular disease.

作者信息

Nawrot Tim, Den Hond Elly, Thijs Lutgarde, Staessen Jan A

机构信息

Studiecoördinatiecentrum, Laboratorium Hypertensie, Department voor Moleculair en Cardiovasculair Onderzoek, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium.

出版信息

Curr Hypertens Rep. 2003 Oct;5(5):372-9. doi: 10.1007/s11906-003-0082-1.

DOI:10.1007/s11906-003-0082-1

PMID:12948429

Abstract

Hypertension is present in 60% to 70% of the population over 60 years of age and may result in cardiovascular complications such as stroke, coronary heart disease, and heart failure. In this review, the role of arterial stiffness, endothelial function, atherosclerosis, and oxidative stress in the pathogenesis of hypertension is discussed extensively. Antihypertensive drug treatment may control high blood pressure and prevent complications. This review summarizes the results of several placebo-controlled and comparative clinical trials that have studied the efficacy of different classes of antihypertensive drugs.

摘要

60岁以上人群中60%至70%患有高血压，高血压可能导致心血管并发症，如中风、冠心病和心力衰竭。在本综述中，将广泛讨论动脉僵硬度、内皮功能、动脉粥样硬化和氧化应激在高血压发病机制中的作用。抗高血压药物治疗可以控制高血压并预防并发症。本综述总结了几项安慰剂对照和比较性临床试验的结果，这些试验研究了不同类别的抗高血压药物的疗效。