Lieu Ann Shung, Hwang Shih Lin, Howng Shen Long
Department of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
J Clin Neurosci. 2003 Sep;10(5):553-6. doi: 10.1016/s0967-5868(02)00305-3.
Breast carcinoma has a high predisposition to metastasize to the brain parenchyma. An association between carcinoma of the breast and intracranial meningioma has been reported. The available published articles regarding patients with intracranial meningioma and breast carcinoma have been reviewed. To the best of our knowledge, 86 cases including our 4 cases have so far been reported. All cases were female, and the mean age was 62.4 years when intracranial meningioma was diagnosed. The mean interval of the 2 tumours was 4.5 years. Twenty-five cases of breast tumour were infiltrating duct carcinomas. The location of intracranial meningioma and pathologic subtype showed no specific predominance. Hormone receptor study was performed in 28 cases. In meningioma, the positive rate of progesterone receptor (32.1%) is higher than oestrogen receptor (7.1%); while the positive rate of oestrogen receptor (53.6%) is higher than the progesterone receptor (42.9%) in breast cancer. A review of this study is presented with emphasis on the existence of intracranial meningioma and breast cancer in one patient at different periods. Lesions of the central nervous system in patients with breast cancer should not be immediately labeled as metastases. Intracranial meningioma should be excluded. Likewise, patients with meningioma should have periodic physical examinations and mammographies whereby disease may be diagnosed and treated at an early stage
乳腺癌极易转移至脑实质。已有报道称乳腺癌与颅内脑膜瘤之间存在关联。我们对已发表的有关颅内脑膜瘤合并乳腺癌患者的文章进行了综述。据我们所知，包括我们的4例病例在内，目前已报道了86例。所有病例均为女性，诊断颅内脑膜瘤时的平均年龄为62.4岁。两种肿瘤的平均间隔时间为4.5年。25例乳腺肿瘤为浸润性导管癌。颅内脑膜瘤的位置和病理亚型无特定优势。对28例患者进行了激素受体研究。在脑膜瘤中，孕激素受体阳性率（32.1%）高于雌激素受体（7.1%）；而在乳腺癌中，雌激素受体阳性率（53.6%）高于孕激素受体（42.9%）。本文对该研究进行了综述，重点关注同一患者在不同时期同时存在颅内脑膜瘤和乳腺癌的情况。乳腺癌患者的中枢神经系统病变不应立即被诊断为转移瘤。应排除颅内脑膜瘤。同样，脑膜瘤患者应定期进行体格检查和乳房X线检查，以便在疾病早期进行诊断和治疗。
