A new wrestler in the battle between alpha- and beta-secretases for cleavage of APP.
作者信息
Neve Rachael L
机构信息
Department of Psychiatry, Harvard Medical School, MRC 223, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.
出版信息
Trends Neurosci. 2003 Sep;26(9):461-3. doi: 10.1016/s0166-2236(03)00231-5.
Abstract
Modulation of the proteases that process the amyloid precursor protein (APP) is a major therapeutic strategy for the treatment and prevention of Alzheimer's disease (AD). The discovery of a novel endogenous modulator of alpha-secretase-mediated, in preference to beta-secretase-mediated, cleavage of APP implicates sumoylation in the etiology of AD, and offers a new therapeutic target for intervention in APP processing.
摘要
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