Celik Ayla, Mazmanci Birgül, Camlica Yusuf, Aşkin Ali, Cömelekoglu Ulkü
Department of Biology, Faculty of Science and Art, Mersin University, 33342 Mersin, Turkey.
Mutat Res. 2003 Aug 5;539(1-2):91-7.
In this study, the genotoxic and cytotoxic potential of lambda-cyhalothrin (LCT), a synthetic pyrethroid insecticide, was investigated in Wistar rat bone-marrow cells, using the structural chromosomal aberration (SCA) and micronucleus (MN) test systems. LCT was administrated to adult female albino rats as repeated i.p. doses of 6.12, 3.06, 0.8 mg/kg BW for 13 days at 48 h intervals. Mitomycin C (MMC) was used as a positive control (2 mg/kg BW). All the doses of LCT increased the number of structural chromosomal aberrations and the frequency of micronucleated erythrocytes, compared with the control group. It was also observed that LCT caused a significant decrease in the number of polychromatic erythrocytes. Our results demonstrate that LCT has a clastogenic/genotoxic potential as measured by the bone marrow SCA and MN tests in Wistar rats.
在本研究中，使用结构染色体畸变（SCA）和微核（MN）检测系统，在Wistar大鼠骨髓细胞中研究了合成拟除虫菊酯杀虫剂氯氟氰菊酯（LCT）的遗传毒性和细胞毒性潜力。以6.12、3.06、0.8mg/kg体重的剂量，每隔48小时腹腔注射成年雌性白化大鼠LCT，持续13天。丝裂霉素C（MMC）用作阳性对照（2mg/kg体重）。与对照组相比，所有剂量的LCT均增加了结构染色体畸变的数量和微核红细胞的频率。还观察到LCT导致多染性红细胞数量显著减少。我们的结果表明，通过Wistar大鼠骨髓SCA和MN试验测定，LCT具有断裂/遗传毒性潜力。
