Department of Biology, Cukurova University Faculty of Sciences and Letters, Adana, Turkey.
Environ Sci Pollut Res Int. 2015 Mar;22(6):4747-52. doi: 10.1007/s11356-014-3734-6. Epub 2014 Oct 24.
Pesticides can cause oxidative stress resulting to deleterious effects in animal metabolisms. Cyfluthrin is a synthetic pyrethroid used worldwide to protect crops and to eliminate pests. Thus, the aim of this study was to investigate the effects of the cyfluthrin on the level of malondialdehyde (MDA) and activities of catalase (CAT), glutathione peroxidase (GPx), and acetylcholinesterase (AChE) in the liver and kidney of Wistar Albino Sprague Dawley rats (Rattus norvegicus var. albinos) following intraperitoneal treatment of cyfluthrin (1.2, 12, and 120 mg/kg b.w./day) for 21 days. Comparisons were made with two control solutions named as serum physiologic and solvent in which cyfluthrin was dissolved. CAT activity in the liver and kidney of rats did not change after the lowest cyfluthrin treatment, while its activity significantly decreased at the higher doses. In general, cyfluthrin significantly decreased the activity of GPx in the liver and kidney at all doses, while MDA levels in the liver increased at all doses. Cyfluthrin significantly decreased AChE activity in the liver of rats at all doses, while this was true at the highest dose for the kidney. This study showed that the studied biomarkers were effective in determining the toxic effects of cyfluthrin. Thus, they should be used to monitor pesticide-affected areas before untargeted animals, including humans who suffer from the use of pesticides.
杀虫剂会导致氧化应激，对动物代谢产生有害影响。氯氟氰菊酯是一种被广泛用于保护作物和消除害虫的合成拟除虫菊酯。因此，本研究旨在研究氯氟氰菊酯对腹腔注射氯氟氰菊酯（1.2、12 和 120mg/kg b.w./天）21 天后 Wistar 白化 Sprague Dawley 大鼠（Rattus norvegicus var. albinos）肝脏和肾脏中丙二醛（MDA）水平和过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）和乙酰胆碱酯酶（AChE）活性的影响。与两种对照溶液（血清生理溶液和溶剂）进行了比较，氯氟氰菊酯溶解在这两种对照溶液中。在接受最低剂量氯氟氰菊酯处理后，大鼠肝脏和肾脏中的 CAT 活性没有变化，而高剂量组的 CAT 活性显著降低。一般来说，氯氟氰菊酯在所有剂量下均显著降低了肝脏和肾脏中 GPx 的活性，而肝脏中的 MDA 水平在所有剂量下均升高。氯氟氰菊酯在所有剂量下均显著降低了大鼠肝脏中的 AChE 活性，而在肾脏中则在最高剂量下才如此。本研究表明，所研究的生物标志物可有效确定氯氟氰菊酯的毒性作用。因此，在未针对目标动物（包括因使用杀虫剂而遭受影响的人类）进行监测之前，应使用这些标志物来监测受杀虫剂影响的地区。
