Neumann I, Mirzaei S, Birck R, Osinger K, Waldherr R, Köhn H D, Meisl F T
Department of Nephrology, Wilhelminenspital, Vienna, Austria.
Rheumatology (Oxford). 2004 Feb;43(2):195-201. doi: 10.1093/rheumatology/keg479. Epub 2003 Aug 29.
To assess the usefulness of somatostatin receptor (SSTR) scintigraphy for the evaluation of disease activity in the upper and lower respiratory tract in ANCA-associated vasculitis (AASV).
Thirty-two consecutive patients with AASV were subjected to SSTR scintigraphy as part of their initial diagnostic evaluation and follow-up. The presence of SSTRs in inflammatory lesions was evaluated with immunohistochemistry in selected cases.
In AASV, specificity of SSTR scintigraphy for active vs non-active disease was 96% for pulmonary disease and 100% for ear, nose and throat (ENT) involvement, while sensitivity was 86% and 68%, respectively. Absence of previously present tracer accumulation characterized treatment responders, and treatment resistance was reflected by repeated positive scintigraphy. We could demonstrate the expression of SSTRs in lung and mucosal biopsies obtained from patients with active Wegener's granulomatosis and with microscopic polyangiitis.
SSTR scintigraphy is useful for the assessment of AASV, indicating disease activity, disease extent and treatment efficacy. SSTRs are expressed in both granulomatous as well as non-granulomatous AASV.
评估生长抑素受体（SSTR）闪烁扫描术在评估抗中性粒细胞胞浆抗体相关性血管炎（AASV）上下呼吸道疾病活动度方面的实用性。
32例连续性AASV患者接受SSTR闪烁扫描术检查，作为其初始诊断评估及随访的一部分。部分病例通过免疫组织化学评估炎性病变中SSTR的存在情况。
在AASV中，SSTR闪烁扫描术对肺部疾病活动期与非活动期疾病的特异性为96%，对耳鼻喉（ENT）受累情况的特异性为100%，而敏感性分别为86%和68%。治疗有反应者表现为先前存在的示踪剂积聚消失，而治疗抵抗则表现为闪烁扫描术反复呈阳性。我们能够证实SSTR在活动性韦格纳肉芽肿病和显微镜下多血管炎患者的肺组织及黏膜活检组织中的表达。
SSTR闪烁扫描术有助于评估AASV，可指示疾病活动度、疾病范围及治疗效果。SSTR在肉芽肿性及非肉芽肿性AASV中均有表达。
