Goldlust M B, Palmer D M, Augustine M A
J Invest Dermatol. 1976 Mar;66(3):157-60. doi: 10.1111/1523-1747.ep12481898.
Formulations of a number of steroids were evaluated after topical application in a reversed passive Arthus test (RPA) in rabbits. Four 21-chlorosteroids in the same cream base were investigated. The preparations of SQ 18,566 (halcinonide) and SQ 20,811 showed anti-edema activity, but those of SQ 15,361 and SQ 20,589 were less active. Ointment formulations of halcinonide also reduced edema in the RPA. These results, coupled with previously reported clinical data, suggest that the RPA might be utilized to distinguish good from poor formulations of anti-inflammatory steroids prior to screening tests or clinical trials in humans.
在兔被动反向 Arthus 试验（RPA）中局部应用后，对多种甾体药物制剂进行了评估。研究了四种在相同乳膏基质中的 21 - 氯甾体。SQ 18,566（卤米松）和 SQ 20,811 的制剂显示出抗水肿活性，但 SQ 15,361 和 SQ 20,589 的制剂活性较低。卤米松的软膏制剂在 RPA 中也减轻了水肿。这些结果，再加上先前报道的临床数据，表明在对人类进行筛选试验或临床试验之前，RPA 可用于区分抗炎甾体药物的优劣制剂。
