防御素：天然免疫的抗菌肽。

Defensins: antimicrobial peptides of innate immunity.

作者信息

Ganz Tomas

机构信息

Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095-1690, USA.

出版信息

Nat Rev Immunol. 2003 Sep;3(9):710-20. doi: 10.1038/nri1180.

DOI:10.1038/nri1180

PMID:12949495

Abstract

The production of natural antibiotic peptides has emerged as an important mechanism of innate immunity in plants and animals. Defensins are diverse members of a large family of antimicrobial peptides, contributing to the antimicrobial action of granulocytes, mucosal host defence in the small intestine and epithelial host defence in the skin and elsewhere. This review, inspired by a spate of recent studies of defensins in human diseases and animal models, focuses on the biological function of defensins.

摘要

天然抗生素肽的产生已成为动植物先天免疫的一种重要机制。防御素是一大类抗菌肽中的不同成员，有助于粒细胞的抗菌作用、小肠中的黏膜宿主防御以及皮肤和其他部位的上皮宿主防御。这篇综述受到近期一系列关于人类疾病和动物模型中防御素研究的启发，重点关注防御素的生物学功能。