Ott Vanessa L, Cambier John C, Kappler John, Marrack Philippa, Swanson Bradley J
Integrated Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, and University of Colorado Health Sciences Center, Denver, Colorado 80206, USA.
Nat Immunol. 2003 Oct;4(10):974-81. doi: 10.1038/ni971. Epub 2003 Aug 31.
Studies in both humans and rodents indicate that CD8+ T cells may be important in allergic inflammation. However, neither the mechanisms that mediate CD8+ T cell recruitment to inflamed tissues nor the relative participation of effector and central memory CD8+ T cells is known. Here we report that activated mast cells induced chemotaxis of effector, but not central memory, CD8+ T cells through production of leukotriene B4 (LTB4). These studies indicate that LTB4 production by activated peripheral leukocytes could be important for the recruitment of effector CD8+ T cells to sites of inflammation.
对人类和啮齿动物的研究表明，CD8 + T细胞可能在过敏性炎症中起重要作用。然而，介导CD8 + T细胞募集到炎症组织的机制以及效应性和中枢记忆性CD8 + T细胞的相对参与情况均尚不清楚。在此，我们报告活化的肥大细胞通过产生白三烯B4（LTB4）诱导效应性而非中枢记忆性CD8 + T细胞的趋化作用。这些研究表明，活化的外周白细胞产生LTB4可能对效应性CD8 + T细胞募集到炎症部位很重要。
