Konovalova N P
Institute of Problems in Chemical Physics, Russian Academy of Sciences.
Bull Exp Biol Med. 2003 Jan;135 Suppl 7:45-7. doi: 10.1023/a:1024714326353.
Antitumor activity of ultralow doses of cytostatic lonidamine and effects of various biological preparations in ultralow doses (chemosensitizer, immunomodulator, and antioxidant) on the efficiency of adriamycin and cisplatin were studied in animals with transplanted tumors. High efficiency of this method was demonstrated. Nitrotriazole chemosensitizer in ultralow doses increased the sensitivity of leukemia P388/rn substrain with multiple drug resistance phenotype to mitomycin C during combination therapy.
在移植瘤动物模型中研究了超低剂量细胞生长抑制剂氯尼达明的抗肿瘤活性以及超低剂量的各种生物制剂（化学增敏剂、免疫调节剂和抗氧化剂）对阿霉素和顺铂疗效的影响。结果表明该方法具有高效性。超低剂量的硝三唑化学增敏剂在联合治疗期间提高了具有多药耐药表型的白血病P388/rn亚株对丝裂霉素C的敏感性。
