普罗托平与阿米替林的抗抑郁特性：对比实验研究
Antidepressant properties of Proproten and amitriptyline: comparative experimental study.
作者信息
Epstein O I, Molodavkin G M, Voronina T A, Sergeeva S A
机构信息
Materia Medica Holding Research-and-Production Company, Moscow.
出版信息
Bull Exp Biol Med. 2003 Jan;135 Suppl 7:123-4. doi: 10.1023/a:1024724023144.
Antidepressant properties of Proproten (antibodies to S100 protein in ultralow doses) were studied on outbred albino rats. The animals were subjected to the Porsolt's test of behavioral helplessness and Nomura's test of forced swimming in a reservoir with freely rotating wheels. Proproten in a dose of 2.5 ml/kg produced a strong antidepressant effect. It was observed after single and repeated (5 days) peroral treatment with the preparation. Proproten decreased the immobility time (Porsolt's test) and increased the number of wheel turns (Nomura's test). The activity of Proproten compared well with the standard preparation amitriptyline. As differentiated from amitriptyline, Proproten did not produce the sedative effect.
在远交系白化大鼠身上研究了Proproten（超低剂量的S100蛋白抗体）的抗抑郁特性。对动物进行行为无助的波索尔特试验和在带有自由旋转轮的水池中进行强迫游泳的野村试验。剂量为2.5毫升/千克的Proproten产生了强烈的抗抑郁作用。在单次和重复（5天）口服该制剂后均观察到这一作用。Proproten缩短了不动时间（波索尔特试验）并增加了轮转次数（野村试验）。Proproten的活性与标准制剂阿米替林相当。与阿米替林不同的是，Proproten没有产生镇静作用。
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