Lo Re Vincent, Fox Kevin R, Ferrari Victor A, Scott Craig H, Kossev Plamen M, Kostman Jay R
Division of Infectious Diseases, Department of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
Am J Hematol. 2003 Sep;74(1):64-7. doi: 10.1002/ajh.10373.
Hypereosinophilia, defined as an absolute eosinophil count exceeding 1,500/mm(3), is caused by a limited number of disorders. Its association with malignancy is a rare occurrence that typically denotes extensive metastasis and a poor prognosis. Several theories have been proposed to explain the hypereosinophilia associated with malignancy, focusing on the production of eosinophilopoietic cytokines by tumors. We describe a patient with hypereosinophilia associated with a cardiac rhabdomyosarcoma, review the etiologies of hypereosinophilia, and discuss the possible mechanisms.
嗜酸性粒细胞增多症定义为绝对嗜酸性粒细胞计数超过1500/mm³，由少数疾病引起。它与恶性肿瘤的关联是一种罕见情况，通常意味着广泛转移和预后不良。已经提出了几种理论来解释与恶性肿瘤相关的嗜酸性粒细胞增多症，重点是肿瘤产生嗜酸性粒细胞生成细胞因子。我们描述了一名患有与心脏横纹肌肉瘤相关的嗜酸性粒细胞增多症的患者，回顾了嗜酸性粒细胞增多症的病因，并讨论了可能的机制。
