大颗粒淋巴细胞白血病T细胞型与自然杀伤细胞型的临床特征
Clinical features in T-cell vs. natural killer-cell variants of large granular lymphocyte leukemia.
作者信息
Neben Michelle A, Morice William G, Tefferi Ayalew
机构信息
Division of Hematology and Internal Medicine; Division of Hematopathology, Mayo Clinic, Mayo Medical School, Rochester, MN 55905, USA.
出版信息
Eur J Haematol. 2003 Oct;71(4):263-5. doi: 10.1034/j.1600-0609.2003.00136.x.
OBJECTIVE
Standard clinical and laboratory evaluations and novel laboratory techniques were used to identify patients with T-cell large granular lymphocyte leukemia (LGLL) and those with natural killer-cell variants of LGLL for comprehensive clinical evaluation.
METHODS
We used bone marrow histologic analysis, immunophenotypic markers of clonality, and T-cell-receptor gene rearrangement studies to identify patients.
RESULTS
The study identified 44 patients with T-cell LGLL and 14 with natural killer-cell LGLL. The two disorders were similar in sex and age distribution of patients; peripheral blood lymphocyte, neutrophil, and platelet counts; and incidence of rheumatoid arthritis. Among the two groups, patients with the T-cell LGLL presented with significantly lower hemoglobin concentrations (P < 0.04) and a higher frequency of palpable splenomegaly (P < 0.01).
CONCLUSION
Overall disease progression and response to immunosuppressive therapy are similar between T-cell and natural killer-cell variants of LGLL.
目的
采用标准临床和实验室评估以及新型实验室技术来识别T细胞大颗粒淋巴细胞白血病（LGLL）患者和自然杀伤细胞型LGLL患者，以进行全面临床评估。
方法
我们使用骨髓组织学分析、克隆性免疫表型标志物以及T细胞受体基因重排研究来识别患者。
结果
该研究识别出44例T细胞LGLL患者和14例自然杀伤细胞LGLL患者。这两种疾病在患者的性别和年龄分布、外周血淋巴细胞、中性粒细胞和血小板计数以及类风湿关节炎发病率方面相似。在两组中，T细胞LGLL患者的血红蛋白浓度显著较低（P<0.04），脾肿大可触及的频率较高（P<0.01）。
结论
LGLL的T细胞型和自然杀伤细胞型在总体疾病进展和对免疫抑制治疗的反应方面相似。
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