Chan I, Calonje E, Whittaker S J
St John's Institute of Dermatology, St Thomas' Hospital, London.
Clin Exp Dermatol. 2003 Sep;28(5):491-2. doi: 10.1046/j.1365-2230.2003.01325.x.
We report a case of Waldenström's macroglobulinaemia that presented with infiltrated skin nodules and plaques but without systemic symptoms. Cutaneous manifestations such as purpura, oedema, urticaria and ulceration may be seen in Waldenström's macroglobulinaemia and are a consequence of hyperviscosity, cryoglobulinaemia and/or tissue deposition of immunoglobulins. Direct cutaneous infiltration by neoplastic lymphoid cells is less common, and very rare as the initial presentation of Waldenström's macroglobulinaemia.
我们报告一例华氏巨球蛋白血症患者，该患者表现为皮肤浸润性结节和斑块，但无全身症状。华氏巨球蛋白血症可能出现紫癜、水肿、荨麻疹和溃疡等皮肤表现，这些是高粘滞血症、冷球蛋白血症和/或免疫球蛋白组织沉积的结果。肿瘤性淋巴细胞直接浸润皮肤较为少见，作为华氏巨球蛋白血症的初始表现则极为罕见。
