Durif F, Deffond D, Eschalier A, Tournilhac M
Service de Neurologie, Hôpital Fontmaure, Clermont-Ferrand.
Rev Neurol (Paris). 1992;148(10):610-4.
Apomorphine, a mixed dopaminergic agonist was given sublingually to 12 patients with Parkinson's disease disabled by severe on-off fluctuations. The patient's mean age was 57 years and the duration of Parkinson's disease was 12 years. All patients were also given domperidone (60 mg/day). Apomorphine was administered as soon as the off periods appeared. On periods were observed in 11 patients, with a mean apomorphine dose of 40 mg for each administration (extremes values: 20-60 mg). One patient had no motor benefit after an apomorphine dose of 120 mg. The mean duration of daily off periods was reduced by 64 per cent in 11 patients, for a mean duration of 8 months (extremes values: 2-12 months). Four patients developed stomatitis or gingival edema and stopped treatment. This pilot study shows that sublingual apomorphine, during a mean period of 8 months, significantly decreases off periods in parkinsonian patients. Others studies are necessary to confirm these results.
对12例因严重的“开-关”波动而致残的帕金森病患者舌下给予阿扑吗啡，一种混合多巴胺能激动剂。患者的平均年龄为57岁，帕金森病病程为12年。所有患者还给予多潘立酮（60毫克/天）。一旦出现“关”期就给予阿扑吗啡。11例患者出现“开”期，每次给药阿扑吗啡的平均剂量为40毫克（极值：20 - 60毫克）。1例患者在给予120毫克阿扑吗啡后未获得运动益处。11例患者每日“关”期的平均时长减少了64%，平均时长为8个月（极值：2 - 12个月）。4例患者出现口腔炎或牙龈水肿并停止治疗。这项初步研究表明，舌下给予阿扑吗啡，在平均8个月的时间里，可显著减少帕金森病患者的“关”期。需要其他研究来证实这些结果。
