Timmer Mark D, Carter Cory, Ambrose Catherine G, Mikos Antonios G
Department of Bioengineering, Rice University, PO Box 1892 MS-142, Houston, TX 77251-1892, USA.
Biomaterials. 2003 Nov;24(25):4707-14. doi: 10.1016/s0142-9612(03)00364-8.
This work presents a new molding process for photo-crosslinked, degradable polymeric networks of poly(propylene fumarate) (PPF) and the crosslinking agent poly(propylene fumarate)-diacrylate (PPF-DA). Transparent room temperature vulcanizing silicone molds were fabricated for parts ranging from simple test coupons to orthopaedic implants. The PPF/PPF-DA resin blend was injected into the cavity and photo-crosslinked as light was transmitted through the mold wall. The volumetric shrinkage, mechanical properties, and the effects of gamma sterilization were reported for molded PPF/PPF-DA networks prepared with varying compositions of the two polymer components. The shrinkage decreased while the mechanical properties displayed a general increasing trend when more of the crosslinking agent was incorporated into the network. Gamma irradiation resulted in an improvement of the mechanical properties. In addition, PPF/PPF-DA replicates of a 70:30 poly(L/DL-lactide) biodegradable fixation plate and a bone allograft interbody fusion spacer were produced to evaluate the performance of PPF/PPF-DA as an orthopaedic implant and allow for a comparison to be made with materials that have been established for clinical use.
这项工作展示了一种用于聚富马酸丙二醇酯（PPF）和交联剂聚富马酸丙二醇酯二丙烯酸酯（PPF-DA）的光交联、可降解聚合物网络的新型成型工艺。制备了透明的室温硫化硅模具，用于制作从简单测试试样到骨科植入物等各种部件。将PPF/PPF-DA树脂混合物注入型腔，并在光线透过模具壁时进行光交联。报告了用两种聚合物组分的不同组成制备的模塑PPF/PPF-DA网络的体积收缩率、机械性能以及伽马灭菌的影响。当更多的交联剂被引入网络时，收缩率降低，而机械性能总体呈上升趋势。伽马辐照导致机械性能得到改善。此外，制作了70:30聚（L/DL-丙交酯）可生物降解固定板和同种异体骨椎间融合器的PPF/PPF-DA复制品，以评估PPF/PPF-DA作为骨科植入物的性能，并与已确立用于临床的材料进行比较。
