Thrivikraman Greeshma, Athirasala Avathamsa, Twohig Chelsea, Boda Sunil Kumar, Bertassoni Luiz E
Division of Biomaterials and Biomechanics, Department of Restorative Dentistry, OHSU School of Dentistry, 2730 SW Moody Avenue, Portland, OR 97201, USA.
Mary and Dick Holland Regenerative Medicine Program, Department of Surgery-Transplant, University of Nebraska Medical Center, Omaha, NE 68198-5965, USA.
Dent Clin North Am. 2017 Oct;61(4):835-856. doi: 10.1016/j.cden.2017.06.003.
Functional reconstruction of craniofacial defects is a major clinical challenge in craniofacial sciences. The advent of biomaterials is a potential alternative to standard autologous/allogenic grafting procedures to achieve clinically successful bone regeneration. This article discusses various classes of biomaterials currently used in craniofacial reconstruction. Also reviewed are clinical applications of biomaterials as delivery agents for sustained release of stem cells, genes, and growth factors. Recent promising advancements in 3D printing and bioprinting techniques that seem to be promising for future clinical treatments for craniofacial reconstruction are covered. Relevant topics in the bone regeneration literature exemplifying the potential of biomaterials to repair bone defects are highlighted.
颅面缺损的功能重建是颅面科学中的一项重大临床挑战。生物材料的出现是一种潜在的替代标准自体/异体移植手术的方法，以实现临床上成功的骨再生。本文讨论了目前用于颅面重建的各类生物材料。还回顾了生物材料作为干细胞、基因和生长因子缓释载体的临床应用。涵盖了3D打印和生物打印技术最近取得的有前景的进展，这些进展似乎对未来颅面重建的临床治疗很有前景。强调了骨再生文献中的相关主题，这些主题例证了生物材料修复骨缺损的潜力。
