Muchmore Steven W, Hajduk Philip J
Abbott Laboratories, Global Pharmaceutical Research Division, 100 Abbott Park Road, Abbott Park, IL 60048, USA.
Curr Opin Drug Discov Devel. 2003 Jul;6(4):544-9.
Crystallography, nuclear magnetic resonance and virtual ligand screening have become common tools in structural approaches to drug discovery. Appropriately used, these techniques are highly complementary and synergistic, significantly enhancing the pace of the discovery process and the quality of compounds selected for further development. The integration of these discovery tools will be discussed, and examples in which the combination of these technologies has impacted on the drug discovery cycle will be highlighted.
晶体学、核磁共振和虚拟配体筛选已成为药物发现结构方法中的常用工具。如果使用得当，这些技术具有高度的互补性和协同性，能显著加快发现过程的速度以及提升为进一步开发而选择的化合物的质量。本文将讨论这些发现工具的整合，并着重介绍这些技术的组合对药物发现周期产生影响的实例。
