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盘基网柄菌Ras亚家族蛋白对细胞骨架的调控

Cytoskeletal regulation by Dictyostelium Ras subfamily proteins.

作者信息

Lim Chinten James, Spiegelman George B, Weeks Gerald

机构信息

Department of Microbiology and Immunology, University of British Columbia, 300-6174 University Boulevard, Vancouver, British Columbia, Canada V6T 1Z3.

出版信息

J Muscle Res Cell Motil. 2002;23(7-8):729-36. doi: 10.1023/a:1024471527153.

DOI:10.1023/a:1024471527153
PMID:12952071
Abstract

The Ras subfamily proteins are monomeric GTPases that function as molecular switches in cellular signal transduction. The roles of six of these proteins in regulating actin cytoskeletal functions in Dictyostelium discoideum are discussed in this review.

摘要

Ras亚家族蛋白是单体GTP酶,在细胞信号转导中起分子开关的作用。本文综述了其中六种蛋白在调节盘基网柄菌肌动蛋白细胞骨架功能中的作用。

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本文引用的文献

1
Pseudopodium dynamics and rapid cell movement in Dictyostelium Ras pathway mutants.盘基网柄菌Ras信号通路突变体中的伪足动力学与细胞快速运动
Cell Motil Cytoskeleton. 2002 Oct;53(2):150-62. doi: 10.1002/cm.10064.
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Evidence for a role for the Dictyostelium Rap1 in cell viability and the response to osmotic stress.盘基网柄菌Rap1在细胞活力及对渗透压应激反应中作用的证据。
J Cell Sci. 2002 Sep 15;115(Pt 18):3675-82. doi: 10.1242/jcs.00039.
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Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis.
朝着真核细胞趋化作用的分子机制迈进。
Mol Biol Cell. 2019 Nov 1;30(23):2873-2877. doi: 10.1091/mbc.E19-07-0393.
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Identification of novel macropinocytosis inhibitors using a rational screen of Food and Drug Administration-approved drugs.采用合理筛选美国食品和药物管理局批准药物的方法鉴定新型巨胞饮抑制剂。
Br J Pharmacol. 2018 Sep;175(18):3640-3655. doi: 10.1111/bph.14429. Epub 2018 Aug 1.
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Excitable Signal Transduction Networks in Directed Cell Migration.定向细胞迁移中的可兴奋信号转导网络。
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Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes.迈向典范:Dictyostelium 和哺乳动物白细胞趋化信号转导的共同机制。
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7
Dictyostelium discoideum SecG interprets cAMP-mediated chemotactic signals to influence actin organization.盘基网柄菌 SecG 蛋白解读 cAMP 介导体化运动信号以影响肌动蛋白组织。
Cytoskeleton (Hoboken). 2013 May;70(5):269-80. doi: 10.1002/cm.21107. Epub 2013 Apr 5.
8
Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs.盘基网柄菌中的环磷酸腺苷信号传导:G蛋白利用特定的Ras鸟苷酸交换因子激活不同的Ras信号通路。
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