Marcinowska-Suchowierska E, Lisawa A, Marowska J, Lorencewicz Z, Tałałaj M, Brzozowski R, Lorenc R
Kliniki Chorób Wewnetrznych Centrum Medycznego Kształcenia Podyplomowego w Warszawie.
Wiad Lek. 1992 Sep;45(17-18):647-54.
In 65 subjects (42 women and 23 men) aged from 40 to 80 years, at risk for primary or secondary osteoporosis development without concomitant diseases affecting renal and hepatic function and vitamin D metabolism, alkaline phosphatase activity (F.A.s) and total calcium level (Cas) were determined in the blood serum, and also the excretion in the morning urine portion of hydroxyproline and calcium was measured in relation to creatinine excretion (FUHpr/kr; FUCa/kr). In each patient an X-ray was done of the thoracolumbar spine, and on its basis the X-ray vertebral index was calculated. The study has been undertaken in order to elucidate whether the above stated compounds regarded as biochemical markers of bone remodelling, and the X-ray vertebral index are useful in the diagnosis of osteoporosis. An increased F.A.s activity in the blood serum, and higher values of the X-ray vertebral index were found both in the group of patients with primary and secondary osteoporosis, in relation to normal values. It was found that FUHpr/kr and FUCa/kr were increased in patients with secondary osteoporosis in comparison to patients with primary osteoporosis. A statistically significant correlation was also noted between FUHpr/kr and FUCa/kr, and F.A.s in patients with primary and secondary osteoporosis. In both studied groups no relationship was found between the value of the X-ray vertebral index, and the levels of biochemical markers of bone remodelling.
在65名年龄在40至80岁之间、有原发性或继发性骨质疏松症发病风险且无影响肾、肝功能及维生素D代谢的伴发疾病的受试者（42名女性和23名男性）中，测定了血清中的碱性磷酸酶活性（F.A.s）和总钙水平（Cas），还测量了早晨尿液中羟脯氨酸和钙相对于肌酐排泄量的排泄情况（FUHpr/kr；FUCa/kr）。对每位患者进行了胸腰椎X线检查，并据此计算X线椎体指数。进行该研究是为了阐明上述被视为骨重塑生化标志物的化合物以及X线椎体指数是否有助于骨质疏松症的诊断。与正常值相比，原发性和继发性骨质疏松症患者组血清中的F.A.s活性均升高，且X线椎体指数值更高。结果发现，继发性骨质疏松症患者的FUHpr/kr和FUCa/kr相较于原发性骨质疏松症患者有所升高。在原发性和继发性骨质疏松症患者中，还发现FUHpr/kr和FUCa/kr与F.A.s之间存在统计学上的显著相关性。在两个研究组中，均未发现X线椎体指数值与骨重塑生化标志物水平之间存在关联。
