用含有硫氰酸酶和硫代硫酸盐的重封红细胞对抗氰化物的致死作用。

Antagonism of the lethal effects of cyanide with resealed erythrocytes containing rhodanese and thiosulfate.

作者信息

Way J L, Cannon E P, Leung P, Hawkins-Zitzer A, Pei L, Petrikovics I

机构信息

Department of Medical Pharmacology & Toxicology, Texas A & M University, College of Medicine, College Station.

出版信息

Adv Exp Med Biol. 1992;326:159-63. doi: 10.1007/978-1-4615-3030-5_19.

DOI:10.1007/978-1-4615-3030-5_19

PMID:1295301

Abstract

A new concept has been presented for the antagonism of cyanide and possibly other chemical toxicants. Until now, only a half dozen truly specific "antidotes" were known. There are many other "antidotes" which merely prevent the absorption or enhance the elimination of a toxic compound rather than specifically destroying the substance to prevent its toxic effect. This new approach has considerable conceptual significance in toxicology, as it suggests the encapsulating other enzymes to degrade various other chemical toxicants. There are many chemical toxicants for which there are no specific antidotes, and the conceptual approach of employing erythrocyte-encapsulated enzyme provides an innovative, specific approach to antagonize the toxic and lethal effects of these chemicals.

摘要

一种针对氰化物以及可能的其他化学毒物的拮抗作用的新概念已被提出。到目前为止，仅知晓六种真正特效的“解毒剂”。还有许多其他“解毒剂”，它们仅仅是阻止毒物吸收或促进其排出，而非特异性地破坏毒物以防止其产生毒性作用。这种新方法在毒理学领域具有相当重要的概念意义，因为它提出了包裹其他酶以降解各种其他化学毒物的设想。有许多化学毒物尚无特效解毒剂，而采用红细胞包裹酶的概念性方法为对抗这些化学物质的毒性和致死效应提供了一种创新的、特异性的途径。