Mallick Netar
Department of Renal Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK.
Nephrol Dial Transplant. 2003 Aug;18 Suppl 6:vi64-7. doi: 10.1093/ndt/gfg1065.
The idiopathic and familial forms of focal glomerulosclerosis, and the similar lesion that occurs in association with HIV infection, are dealt with elsewhere in this supplement. This article highlights conditions where FSGS develops, apparently, as a phenomenon secondary to another defined pathology. It may occur in a setting of normal renal mass associated with (i) an immunological aberration such as thymoma, or (ii) in a non-immunological setting associated with increased intra-glomerular pressure or deposition of inappropriate material. FSGS may also be found (iii) in association with a reduced renal mass that may, for example, follow an ischaemic renal insult. The pathogenetic mechanism(s) involved remain unclear.
特发性和家族性局灶节段性肾小球硬化，以及与HIV感染相关的类似病变，在本增刊的其他部分讨论。本文重点介绍了FSGS显然作为另一种明确病理的继发现象而发生的情况。它可能发生在肾实质正常的情况下，与（i）免疫异常如胸腺瘤相关，或（ii）与肾小球内压力升高或不适当物质沉积相关的非免疫环境中。FSGS也可能（iii）与肾实质减少相关，例如在缺血性肾损伤后。所涉及的发病机制仍不清楚。
