与黄素化囊肿相关的难治性妊娠剧吐、短暂性甲状腺功能亢进和宫内生长受限。病例报告。

Intractable hyperemesis gravidarum, transient hyperthyroidism and intrauterine growth restriction associated with hyperreactio luteinalis. A case report.

作者信息

Gherman Robert B, Mestman Jorge H, Satin Andrew J, Goodwin T Murphy

机构信息

Division of Maternal/Fetal Medicine, Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, National Naval Medical Center, Bethesda Naval Hospital, Bethesda, Maryland, USA.

出版信息

J Reprod Med. 2003 Jul;48(7):553-6.

PMID:12953331

Abstract

BACKGROUND

Hyperreactio luteinalis represents benign pregnancy-associated ovarian enlargement caused by multiple theca-lutein cysts. It is usually discovered incidentally at the time of ultrasound, cesarean section or postpartum tubal ligation with the majority of cases asymptomatic.

CASE

A 30-year-old, nulliparous, West African woman initially presented with hyperemesis gravidarum at 8 weeks' gestation. Bilateral, 10-cm theca-lutein cysts were discovered on ultrasound at 27 weeks. Despite intravenous hyperalimentation, the patient continued to have intractable vomiting and transient episodes of hyperthyroidism. She delivered a 1,450-g, female infant at 33 weeks; findings at the time of cesarean delivery included bilateral 10 x 8-cm theca-lutein cysts. Laboratory evaluation confirmed clinical evidence of virilization, with markedly elevated levels of testosterone and androstenedione.

CONCLUSION

Intractable hyperemesis gravidarum, transient hyperthyroidism and intrauterine growth restriction may be associated with hyperreactio luteinalis.

摘要

背景

黄素化囊肿过度反应表现为多个卵泡膜黄素囊肿引起的与妊娠相关的良性卵巢增大。通常在超声检查、剖宫产或产后输卵管结扎时偶然发现，大多数病例无症状。

病例

一名30岁未生育的西非妇女，妊娠8周时最初出现妊娠剧吐。妊娠27周超声检查发现双侧10厘米的卵泡膜黄素囊肿。尽管进行了静脉高营养治疗，但患者仍持续顽固性呕吐并伴有短暂的甲状腺功能亢进发作。她在33周时分娩了一名1450克的女婴；剖宫产时发现双侧有10×8厘米的卵泡膜黄素囊肿。实验室检查证实了男性化的临床证据，睾酮和雄烯二酮水平明显升高。