Sun S, Zhou Q, Yu J, Hu X
Department of Chemistry, Tsinghua University, 100084 Beijing.
Guang Pu Xue Yu Guang Pu Fen Xi. 2000 Apr;20(2):199-202.
The latest development of the molecular vibrational spectroscopy (Fourier Transform Raman Spectroscopy and Fourier Transform Infraed Spectroscopy) and the latest application of the non-destructive identification, quantitative analysis, thermal-stability monitoring and Chinese medicine optimizing were described in this paper. Some Chinese crude herbs can be directly and quickly identified by Fourier Transform Raman spectroscopy (FT - Raman) and Diffused Reflection Fourier Transform Infrared Spectroscopy (DR-FTIR). The content of Chinese herbs, medicine and medicament can be quantified without destruction by Diffused Reflection Fourier Transform and Near Infrared Spectroscopy (DR-NIR-FTIR). The mechanism of interaction between the Chinese medicine and some cells or bacteria can be in situ monitored by FT-Raman and HATR-FTIR. Best medicine could be selected and medicament could be optimized according to the injury degree of the cell or bacteria. The decomposing and degenerating process of medicines can also be timely monitored by FT-Raman and the temperature controlled FTIR. These are the latest use of molecular spectroscopy in Chinese medicine. The fast indentification, quantitative analysis monitoring, thermal stability predicting and the optimizing of Chinese herbs, medicine and medicament can be guided by the above mentioned methods. It is proved that these methods are nondestructive to samples, fast accurate, and easy to use.
本文介绍了分子振动光谱（傅里叶变换拉曼光谱和傅里叶变换红外光谱）的最新进展及其在无损鉴定、定量分析、热稳定性监测和中药优化方面的最新应用。一些中药材可通过傅里叶变换拉曼光谱（FT - Raman）和漫反射傅里叶变换红外光谱（DR - FTIR）直接快速鉴定。中药材、成药和药剂的含量可通过漫反射傅里叶变换和近红外光谱（DR - NIR - FTIR）进行无损定量。中药与某些细胞或细菌之间的相互作用机制可通过FT - Raman和HATR - FTIR进行原位监测。可根据细胞或细菌的损伤程度选择最佳药物并优化药剂。药物的分解和降解过程也可通过FT - Raman和温控FTIR及时监测。这些是分子光谱在中药领域的最新应用。上述方法可指导中药材、成药和药剂的快速鉴定、定量分析监测、热稳定性预测及优化。事实证明，这些方法对样品无损、快速准确且易于使用。
