Silbaugh S A, Sofia M J, Hamill R L, Stengel P W
Eli Lilly and Company, Indianapolis, Indiana 46285.
Agents Actions. 1992 Nov;37(3-4):188-90. doi: 10.1007/BF02028105.
The pulmonary effects of inhaled A23187 are reviewed. Guinea pigs challenged with this divalent cationic ionophore rapidly develop airway obstruction, which is maintained for at least 4 h. Pulmonary inflammation and increased airway responsiveness are also observed. Pharmacologic manipulations suggest that these actions are due to the release of multiple mediators. We have found A23187 challenge to be valuable as an approach for testing potential asthma drugs.
本文综述了吸入A23187对肺部的影响。用这种二价阳离子离子载体攻击豚鼠后，它们会迅速出现气道阻塞，并至少持续4小时。还观察到肺部炎症和气道反应性增加。药理学操作表明，这些作用是由于多种介质的释放所致。我们发现，用A23187进行攻击作为一种测试潜在哮喘药物的方法很有价值。
