Watkins B M, Nowell F
Division of Zoology, School of Animal and Microbial Sciences, The University of Reading, Whiteknights, PO Box 228, Reading RG6 6AJ, UK.
Parasitology. 2003 Aug;127(Pt 2):115-20. doi: 10.1017/s0031182003003378.
Numbers of leucocytes in squirrels with gametocytes of Hepatozoon in their blood (infected) were compared with animals without gametocytes (uninfected). Typical values for leucocytes/mm3 blood in uninfected squirrels were: leucocytes 5.7 x 10(3), granulocytes 3.4 x 10(3), lymphocytes 2.0 x 10(3) and monocytes 0.3 x 10(3) cells. Infection caused an increase in monocytes, lymphocytes and granulocytes, and there was a significant positive association between parasitaemia level and numbers of both total leucocytes and monocytes. Infected animals had more uninfected monocytes/mm3 blood than did uninfected animals. The proportions of monocytes were more variable over time in infected animals, but no shift between infected and uninfected status was detected. Transfer of serum from infected squirrels to mice resulted in elevated counts of total blood leucocytes, monocytes and granulocytes, but not of lymphocytes, as compared with controls. Serum from squirrels with high parasitaemias had a more marked effect than serum from squirrels with low parasitaemias. Results indicate an infection-related monocytosis, possibly controlled by cytokines, that increases the number of cells available for invasion by gametocytes, thus enhancing the chances of parasite transmission.
将血液中带有肝簇虫配子体的松鼠（受感染）的白细胞数量与无配子体的动物（未受感染）进行比较。未受感染松鼠每立方毫米血液中白细胞的典型值为：白细胞5.7×10³、粒细胞3.4×10³、淋巴细胞2.0×10³和单核细胞0.3×10³个细胞。感染导致单核细胞、淋巴细胞和粒细胞增加，并且血症水平与总白细胞和单核细胞数量之间存在显著正相关。受感染动物每立方毫米血液中未感染的单核细胞比未受感染动物更多。在受感染动物中，单核细胞的比例随时间变化更大，但未检测到感染和未感染状态之间的转变。与对照组相比，将受感染松鼠的血清转移到小鼠体内会导致全血白细胞、单核细胞和粒细胞计数升高，但淋巴细胞计数无变化。高血症松鼠的血清比低血症松鼠的血清具有更显著的效果。结果表明存在与感染相关的单核细胞增多症，可能由细胞因子控制，这增加了可供配子体侵入的细胞数量，从而提高了寄生虫传播的机会。
