Kramer Kristin M, Cushing Bruce S, Carter C Sue
The Brain-Body Center, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA.
Physiol Behav. 2003 Sep;79(4-5):775-82. doi: 10.1016/s0031-9384(03)00175-6.
Both exogenous and endogenous oxytocin (OT) are associated with an attenuated stress response. Increased levels of OT in the early postnatal period have been shown to affect behavior and physiology in rodents, and these effects last into adulthood, suggesting an organizational role for OT during development. We investigated the effects of neonatal exposure to OT on the development of the stress response in male and female prairie voles (Microtus ochrogaster). OT or an OT antagonist (OTA) was administered either on postnatal day 1 (single, D1) or days 1-7 (repeated, D1-7) and then on day 8 the response to social isolation was assessed by quantifying ultrasonic vocalizations (USVs) and measuring plasma corticosterone (CORT). Treatment effects were observed only in females. A single treatment with OTA was associated with a decrease in vocalizations, while repeated treatment produced an increase in vocalizations. A single treatment with either saline or OTA increased basal CORT. The results suggest that endogenous OT may be involved in the development of the stress response in females.
外源性和内源性催产素（OT）均与应激反应减弱有关。研究表明，出生后早期OT水平的升高会影响啮齿动物的行为和生理，且这些影响会持续到成年期，这表明OT在发育过程中具有组织作用。我们研究了新生期暴露于OT对雄性和雌性草原田鼠（Microtus ochrogaster）应激反应发育的影响。在出生后第1天（单次，D1）或第1 - 7天（重复，D1 - 7）给予OT或OT拮抗剂（OTA），然后在第8天通过量化超声波发声（USV）和测量血浆皮质酮（CORT）来评估对社会隔离的反应。仅在雌性中观察到治疗效果。单次给予OTA与发声减少有关，而重复治疗则导致发声增加。单次给予生理盐水或OTA均会增加基础CORT。结果表明，内源性OT可能参与了雌性应激反应的发育。
