人异种移植瘤中O6-烷基鸟嘌呤-DNA烷基转移酶的肿瘤水平及对卡氮芥的敏感性
Tumour levels of O6-alkylguanine-DNA-alkyltransferase and sensitivity to BCNU of human xenografts.
作者信息
Tagliabue G, Citti L, Massazza G, Damia G, Giavazzi R, D'Incalci M
机构信息
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
出版信息
Anticancer Res. 1992 Nov-Dec;12(6B):2123-5.
Tumour levels of O6-alkylguanine-DNA-alkyltransferase (O6 AT) and glutathione content (GSH) were correlated with 1, 3-Bis (2-chloroethyl)-1-nitrosourea (BCNU) sensitivity in two human ovarian cancer xenografts (HOC8 and HOC18) and in two human glioblastoma xenografts (HG12 and HG15). HOC8 and HOC18, which were not responsive to BCNU treatment, showed O6 AT levels 14 and 23-fold higher than HG12 that was moderately sensitive to the same BCNU treatment. HG15, which was more sensitive to BCNU than HG12, showed significantly lower O6 AT levels. GSH levels were similar in all tumor xenografts. These data further stress the importance of O6 AT level as a relevant parameter for nitrosourea response in human tumours.
在两个人卵巢癌异种移植瘤（HOC8和HOC18）以及两个人胶质母细胞瘤异种移植瘤（HG12和HG15）中，O6-烷基鸟嘌呤-DNA烷基转移酶（O6 AT）的肿瘤水平和谷胱甘肽含量（GSH）与1,3-双（2-氯乙基）-1-亚硝基脲（BCNU）敏感性相关。对BCNU治疗无反应的HOC8和HOC18，其O6 AT水平比中度敏感于相同BCNU治疗的HG12分别高14倍和23倍。对BCNU比HG12更敏感的HG15，其O6 AT水平显著更低。所有肿瘤异种移植瘤中的GSH水平相似。这些数据进一步强调了O6 AT水平作为人类肿瘤中硝基脲反应相关参数的重要性。
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