Mizukami Y, Nonomura A, Michigishi T, Kosaka T, Noguchi M, Nakamura S, Hashimoto T
Pathology Section, Kanazawa University Hospital, Japan.
Anticancer Res. 1992 Nov-Dec;12(6B):2213-7.
The occurrence of aneuploidy in 108 normal, benign and malignant thyroid tissues was evaluated by DNA flow cytometry. Aneuploid cell populations were found in 60% of the papillary carcinomas, 67% of the follicular carcinomas, 52% of the follicular adenomas and in 10% of the multinodular goiters. None of the non-neoplastic thyroid lesions (chronic thyroiditis and Graves' disease) showed aneuploidy. No significant differences in frequency of aneuploidy and DNA index were found between the well-differentiated and trabecular types of the papillary carcinomas (53%; 1.29 +/- 0.10 vs 75%; 1.30 +/- 0.10, respectively), although the latter type of papillary carcinomas have been shown to be associated with a more aggressive clinical behavior. Also no differences in frequency of aneuploidy were noted between the follicular carcinomas and the follicular adenomas, but the DNA index was significantly higher in the former. These findings indicate that flow cytometric analysis of DNA content may not be helpful in the evaluation of the clinical behavior of papillary carcinomas or in the determination of malignancy of follicular tumors, but may be useful in differentiating neoplastic from non-neoplastic thyroid lesions.
通过DNA流式细胞术评估了108例正常、良性及恶性甲状腺组织中异倍体的发生情况。在60%的乳头状癌、67%的滤泡状癌、52%的滤泡性腺瘤以及10%的结节性甲状腺肿中发现了异倍体细胞群。非肿瘤性甲状腺病变（慢性甲状腺炎和格雷夫斯病）均未显示异倍体。在乳头状癌的高分化型和小梁型之间，异倍体频率和DNA指数未发现显著差异（分别为53%；1.29±0.10与75%；1.30±0.10），尽管后一种类型的乳头状癌已被证明与更具侵袭性的临床行为相关。滤泡状癌和滤泡性腺瘤之间的异倍体频率也未发现差异，但前者的DNA指数显著更高。这些发现表明，DNA含量的流式细胞术分析可能无助于评估乳头状癌的临床行为或确定滤泡性肿瘤的恶性程度，但可能有助于区分肿瘤性与非肿瘤性甲状腺病变。
