Toxicokinetic assessment of methylphenidate (Ritalin(R)) in a 13-week oral (gavage) toxicity study in rats using an enantiomeric liquid chromatography/tandem mass spectrometry assay. - Suppr | 超能文献

Toxicokinetic assessment of methylphenidate (Ritalin(R)) in a 13-week oral (gavage) toxicity study in rats using an enantiomeric liquid chromatography/tandem mass spectrometry assay.

作者信息

Bakhtiar Ray, Tse Francis L S

出版信息

Rapid Commun Mass Spectrom. 2003;17(18):2160-2. doi: 10.1002/rcm.1167.

DOI:10.1002/rcm.1167

Abstract

摘要

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1

Toxicokinetic assessment of methylphenidate (Ritalin(R)) in a 13-week oral (gavage) toxicity study in rats using an enantiomeric liquid chromatography/tandem mass spectrometry assay.

Rapid Commun Mass Spectrom. 2003;17(18):2160-2. doi: 10.1002/rcm.1167.

2

Toxicokinetic assessment of methylphenidate (Ritalin) enantiomers in pregnant rats and rabbits.哌甲酯（利他林）对映体在妊娠大鼠和家兔体内的毒代动力学评估。

Biomed Chromatogr. 2004 Jun;18(5):275-81. doi: 10.1002/bmc.313.

3

Toxicokinetic assessment of methylphenidate (Ritalin) in a 13-week oral toxicity study in dogs.在一项为期13周的犬类口服毒性研究中对哌甲酯（利他林）进行的毒代动力学评估。

Biomed Chromatogr. 2004 Jan;18(1):45-50. doi: 10.1002/bmc.290.

4

In vitro dissolution and in vivo oral absorption of methylphenidate from a bimodal release formulation in healthy volunteers.健康志愿者中，来自双峰释放制剂的哌甲酯的体外溶出和体内口服吸收情况。

Biopharm Drug Dispos. 2004 Mar;25(2):91-8. doi: 10.1002/bdd.390.

5

Dose-related immunohistochemical and ultrastructural changes after oral methylphenidate administration in cerebrum and cerebellum of the rat.口服哌甲酯后大鼠大脑和小脑的剂量相关免疫组织化学和超微结构变化。

World J Biol Psychiatry. 2009;10(4 Pt 2):531-43. doi: 10.1080/15622970903176683.

6

Comparative bioavailability of single-dose methylphenidate from a multilayer-release bead formulation and an osmotic system: a two-way crossover study in healthy young adults.多层缓释微丸制剂和渗透系统中单剂量哌甲酯的相对生物利用度：健康年轻成年人的双向交叉研究。

Clin Ther. 2008 Jan;30(1):59-69. doi: 10.1016/j.clinthera.2008.01.002.

7

Assessment of pharmacokinetics and pharmacodynamic effects related to abuse potential of a unique oral osmotic-controlled extended-release methylphenidate formulation in humans.评估一种独特的口服渗透控释哌甲酯制剂在人体中的药代动力学及与滥用可能性相关的药效学效应。

J Clin Pharmacol. 2007 Dec;47(12):1476-88. doi: 10.1177/0091270007308615. Epub 2007 Oct 25.

8

Juvenile toxicity assessment of d,l-methylphenidate in rats.大鼠中d，l-哌醋甲酯的幼年毒性评估

Birth Defects Res B Dev Reprod Toxicol. 2008 Feb;83(1):48-67. doi: 10.1002/bdrb.20143.

9

A 90-day oral gavage toxicity study of d-methylphenidate and d,l-methylphenidate in beagle dogs.右旋哌甲酯和消旋哌甲酯对比格犬的90天经口灌胃毒性研究。

Int J Toxicol. 2003 May-Jun;22(3):215-26. doi: 10.1080/10915810305100.

10

Ethylphenidate formation in human subjects after the administration of a single dose of methylphenidate and ethanol.

Drug Metab Dispos. 2000 Jun;28(6):620-4.

引用本文的文献

1

Behavioral, Neurochemical and Developmental Effects of Chronic Oral Methylphenidate: A Review.慢性口服哌甲酯的行为、神经化学和发育影响：综述

J Pers Med. 2023 Mar 23;13(4):574. doi: 10.3390/jpm13040574.

2

Acute oral administration of low doses of methylphenidate targets calretinin neurons in the rat septal area.急性口服低剂量哌甲酯作用于大鼠隔区的钙视网膜蛋白神经元。

Front Neuroanat. 2015 Mar 23;9:33. doi: 10.3389/fnana.2015.00033. eCollection 2015.

3

A review of psychostimulant-induced neuroadaptation in developing animals.发育中动物的精神兴奋剂诱导的神经适应性综述。

Neurosci Bull. 2011 Jun;27(3):197-214. doi: 10.1007/s12264-011-1004-x.

4

Methylphenidate and its isomers: their role in the treatment of attention-deficit hyperactivity disorder using a transdermal delivery system.哌甲酯及其异构体：经皮给药系统在注意缺陷多动障碍治疗中的作用

CNS Drugs. 2006;20(9):713-38. doi: 10.2165/00023210-200620090-00002.