两株小鼠中，分节丝状菌对回肠的定殖程度不同。

Different degree of ileal colonization by segmented, filamentous bacteria in two strains of mice.

作者信息

Klaasen H L, Peters B, Koopman J P, Poelma F G, van den Brink M E, Bakker M H, Beynen A C

机构信息

Central Animal Laboratory, Catholic University of Nijmegen, The Netherlands.

出版信息

J Exp Anim Sci. 1992 Dec;35(3):103-9.

PMID:1295575

Abstract

Segmented, filamentous bacteria (SFBs) are autochthonous, apathogenic inhabitants of the ileum of various animal species. Outbred Swiss (Cpb:SE) mice have significantly higher degrees of SFB colonization than do inbred BALB/c mice. The present studies were carried out to identify determinants of this strain difference. In a cross-fostering experiment it was shown that SFB colonization of the pups is determined by the strain of the pups themselves rather than by the strain of the nursing dam. Thus, maternal effects may not be involved in SFB colonization. In a cross-infecting experiment using germ-free and SFB-positive animals of the two mouse strains, it was found that ileal SFB colonization is determined by host characteristics rather than by origin of the SFBs. Thus, SFBs that are specific for a given mouse strain may not exist in the two strains of mice. It is concluded that the mouse strain difference in SFB colonization is determined by host characteristics, which probably have a genetic basis.

摘要

分段丝状细菌（SFBs）是各种动物物种回肠中的本土非致病性居民。远交系瑞士（Cpb:SE）小鼠的SFB定殖程度明显高于近交系BALB/c小鼠。开展本研究以确定这种品系差异的决定因素。在一项交叉寄养实验中发现，幼崽的SFB定殖由幼崽自身的品系决定，而非由哺乳母鼠的品系决定。因此，母体效应可能不参与SFB定殖。在一项使用两种小鼠品系的无菌和SFB阳性动物进行的交叉感染实验中，发现回肠SFB定殖由宿主特征决定，而非由SFB的来源决定。因此，两种小鼠品系中可能不存在特定于某一给定小鼠品系的SFB。得出的结论是，小鼠品系在SFB定殖方面的差异由宿主特征决定，而宿主特征可能具有遗传基础。